Whilst these lower amounts of exposure are more unlikely to generate the frequent ‑reactions seen with oral metronidazole, the possibility of these and other reactions can not be excluded presently.
disulfiram increases toxicity of metronidazole topical by decreasing metabolism. Small/Significance Unidentified. Increased CNS & cardiac toxicity with oral metronidazole and disulfiram; not as likely to happen with topical administration on account of low absorption.
There have been no deaths or serious adverse events relevant to drug therapy in clinical trials involving 800 non-Expecting Women of all ages who obtained METROGEL-VAGINAL.
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Specific experiments of metronidazole levels in human milk adhering to intravaginally administered metronidazole haven't been performed. On the other hand, metronidazole is secreted in human milk in concentrations comparable to All those present in plasma pursuing oral administration of metronidazole.
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WARNINGS If sizeable discomfort develops from using this medication, discontinue use and speak to your doctor.
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